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International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment - INSIGHT

Myocardial infarction or stroke in the 12 months prior to entering the study, or patients whose ejection fraction post-MI is Composite of death from any cardiovascular or cerebrovascular cause, non-fatal stroke, myocardial infarction, and heart failure. Total mortality Death from a vascular cause Non-fatal vascular events including transient ischemic attacks, angina new or worsening , and renal failure.

Nifedipine, 30 mg daily; or co-amilozide hydrochlorothiazide 25 mg, amiloride 2. All patients received one active and one placebo tablet taken at the same time of day. The primary outcome Composite of death from any cardiovascular or cerebrovascular cause, non-fatal stroke, myocardial infarction, and heart failure occurred in 6. Nifedipine once daily and co-amilozide had a similar efficacy in high risk patients with hypertension, suggesting the choice of drug can be determined by tolerability and blood-pressure response rather than long-term safety or efficacy.

Description: The INSIGHT trial compared the effects of the calcium-channel blocker nifedipine once daily with the diuretic combination co-amilozide on cardiovascular mortality and morbidity in highrisk patients with hypertension.

Amilco (Co-Amilozide) - Report on Amilco (Co-Amilozide) as a Banned Substance

Exclusions: Documented secondary or malignant hypertension. Principal Findings: The primary outcome Composite of death from any cardiovascular or cerebrovascular cause, non-fatal stroke, myocardial infarction, and heart failure occurred in 6. Interpretation: Nifedipine once daily and co-amilozide had a similar efficacy in high risk patients with hypertension, suggesting the choice of drug can be determined by tolerability and blood-pressure response rather than long-term safety or efficacy.

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